Research2

We are exploring the genetics, metabolism, evolution, cell biology, and pathogenicity of clinically relevant and diverse bacterial pathogens: important causes of diarrheal and systemic diseases worldwide. Our work spans a large terrain that ranges from questions concerning basic mechanisms underlying bacterial cell processes (e.g. the genesis of cell polarity), to uncovering key host responses to bacterial infection, to the development of new therapeutics and vaccines for emerging pandemics. We apply bacterial genetics, host animal model development, and high throughput sequencing and to issues we are exploring.


Pathogens we study:

Vibrio spp.
V. cholerae and parahemolyticus metabolism and vaccine development

EHEC.
Shiga toxin-producing Escherichia coli host colonization and pathogenesis

Listeria monocytogenes.
Listeria colonization dynamics and host responses to infection

Shigella flexneri.
Genetics of shigella flexneri pathogenesis and animal model development

Salmonella spp.
Salmonella virulence factors and host requirements for enteric infection

Serratia marcescens
Serratia marcescens
antibiotic resistance mechanisms


Techniques we employ:

Transposon Mutagenesis and High-Throughput Sequencing (TnSeq)

RNASeq

Quantitative Proteomics

Animal Model Development

Bacterial Genetics


Please contact us for more information on these research directions