Sören Abel

Curriculum Vitae

Sören Abel
Postdoc (Infection Biology), Harvard Medical School (since 2012)
Postdoc (Molecular Microbiology), Biozentrum, University of Basel (2008-2012)
Ph.D. (Molecular Microbiology), Biozentrum, University of Basel (2008)
Sören Abel Contact:
e-mail: abel.soren@gmail.com ( abel NULL.soren null@null gmail NULL.com)

Research area:

Pathogens have developed various ways of ensuring their efficient transmission. These include mechanisms that allow the bacteria to leave the host efficiently, promote survival during the passage to the next host, facilitate efficient uptake by the latter, and aid in overcoming host protection mechanisms. To date, molecular dissection of factors that control transmission of bacterially based infectious diseases has been limited, due to the absence of animal models of transmission. I am using a recently developed infant rabbit transmission model to study the molecular mechanisms that facilitate transmission of Vibrio cholerae, the causative agent of cholera. My goal is to identify important transmission factors and characterize their effect at various steps during transmission. Understanding transmission might open new, promising approaches to limited cholera outbreaks and would therefore be an important contribution to public health.

Recent Publications:

An overview of all publications can be found here (http://scholar NULL.google NULL.com/citations?user=kBjbO_AAAAAJ&hl=en).

Abel S, Bucher T*, Nicollier M*, Hug I, Kaever V, Abel zur Wiesch P, and Jenal U. Bi-modal Distribution of the Second Messenger c-di-GMP Controls Cell Fate and Asymmetry during the Caulobacter Cell Cycle. PLoS GENET (2013) 9(9): e1003744. doi:10.1371/journal.pgen.1003744

Abel S*, Chien P*, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, and Jenal U. Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. MOL CELL (2011):550-560.

Diepold A, Amstutz M, Abel S, Sorg I, Jenal U, and Cornelis GR. Deciphering the assembly of the Yersinia type III secretion injectisome. EMBO (2010):1-13.

Abel S, and Jenal U. Role of cyclic di-GMP in Caulobacter crescentus development and cell cycle control. In Wolfe AJ, and Visick KL (ed.) in: The second messenger cyclic -di-GMP. ASM PRESS, Washington, DC (2010):120-136.

Duerig A, Abel S, Folcher M, Nicollier M, Schwede T, Amiot N, Giese B, and Jenal U. Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression. GENES & DEVELOPMENT (2009) 23:93–104.

Paul R, Jaeger T*, Abel S*, Wiederkehr I, Folcher M, Biondi EG, Laub MT, and Jenal U. Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate. CELL (2008) 133:452–61.

Paul R, Abel S, Wassmann P, Beck A, Heerklotz H, and Jenal U. Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. J BIOL CHEM. (2007), 282(40):29170-7.

Abel S*, Hundhausen C*, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, and Ludwig A. The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J IMMUNOL (2004) 172(10):6362-72.