Brigid Davis

Curriculum Vitae

Brigid Davis
Instructor, Harvard Medical School (since 2007)
Research Associate (Microbiology and Molecular Biology), Tufts University School of Medicine (2003-2007)
Postdoctoral Fellow (Infectious Disease and Microbiology), New England Medical Center (1998-2003)
Ph.D. (Biology), M.I.T. (1998)
A.B. (Biochemistry) Harvard University (1988)
Contact:
e-mail: bdavis@rics.bwh.harvard.edu ( bdavis null@null rics NULL.bwh NULL.harvard NULL.edu)

Recent Publications:

1: Ritchie JM, Rui H, Zhou X, Iida T, Kodama T, Ito S, Davis BM, Bronson RT, Waldor MK. Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog. 2012

2: Ritchie JM, Greenwich JL, Davis BM, Bronson RT, Gebhart D, Williams SR, Martin D, Scholl D, Waldor MK. An Escherichia coli O157-specific engineered pyocin prevents and ameliorates infection by E. coli O157:H7 in an animal model of diarrheal disease. Antimicrob Agents Chemother. 2011 Dec;55(12):5469-74.

3: Yamaichi Y, Gerding MA, Davis BM, Waldor MK. Regulatory cross-talk links Vibrio cholerae chromosome II replication and segregation. PLoS Genet. 2011 Jul;7(7):e1002189. Epub 2011 Jul 21.

4: Cava F, de Pedro MA, Lam H, Davis BM, Waldor MK. Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids. EMBO J. 2011 Jul 26;30(16):3442-53.

5: Ringgaard S, Schirner K, Davis BM, Waldor MK. A family of ParA-like ATPases promotes cell pole maturation by facilitating polar localization of chemotaxis proteins. Genes Dev. 2011 Jul 15;25(14):1544-55.

6: Le Roux F, Davis BM, Waldor MK. Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria. Nucleic Acids Res. 2011 Feb;39(3):1004-13.

7: Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK. Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids. Environ Microbiol. 2011 Feb;13(2):296-306. doi: 10.1111/j.1462-2920.2010.02329.x.

8: Shakhnovich EA, Davis BM, Waldor MK. Hfq negatively regulates type III secretion in EHEC and several other pathogens. Mol Microbiol. 2009 Oct;74(2):347-63.

9: Davis BM, Waldor MK. High-throughput sequencing reveals suppressors of Vibrio cholerae rpoE mutations: one fewer porin is enough. Nucleic Acids Res. 2009 Sep;37(17):5757-67.

10: Ho TD, Davis BM, Ritchie JM, Waldor MK. Type 2 secretion promotes enterohemorrhagic Escherichia coli adherence and intestinal colonization. Infect Immun. 2008 May;76(5):1858-65.

11: Davis BM, Waldor MK. RNase E-dependent processing stabilizes MicX, a Vibrio cholerae sRNA. Mol Microbiol. 2007 Jul;65(2):373-85.

12: Mathur J, Davis BM, Waldor MK. Antimicrobial peptides activate the Vibrio cholerae σE regulon through an OmpU-dependent signalling pathway. Mol Microbiol. 2007 Feb;63(3):848-58.

13: Budde PP, Davis BM, Yuan J, Waldor MK. Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J Bacteriol. 2007 Jan;189(2):491-500.

14: Quinones M, Davis BM, Waldor MK. Activation of the Vibrio cholerae SOS response is not required for intestinal cholera toxin production or colonization. Infect Immun. 2006 Feb;74(2):927-30.

15: Livny J, Fogel MA, Davis BM, Waldor MK. sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes. Nucleic Acids Res. 2005 Jul 26;33(13):4096-105.

16: McLeod SM, Kimsey HH, Davis BM, Waldor MK. CTXphi and Vibrio cholerae: exploring a newly recognized type of phage-host cell relationship. Mol Microbiol. 2005 Jul;57(2):347-56. Review.

17: Davis BM, Quinones M, Pratt J, Ding Y, Waldor MK. Characterization of the small untranslated RNA RyhB and its regulon in Vibrio cholerae. J Bacteriol. 2005 Jun;187(12):4005-14.

18: Ding Y, Davis BM, Waldor MK. Hfq is essential for Vibrio cholerae virulence and downregulates sigma expression. Mol Microbiol. 2004 Jul;53(1):345-54.

19: Davis BM, Waldor MK. Filamentous phages linked to virulence of Vibrio cholerae. Curr Opin Microbiol. 2003 Feb;6(1):35-42. Review.

20: Davis BM, Kimsey HH, Kane AV, Waldor MK. A satellite phage-encoded antirepressor induces repressor aggregation and cholera toxin gene transfer. EMBO J. 2002 Aug 15;21(16):4240-9.

21: Davis BM, Moyer KE, Boyd EF, Waldor MK. CTX prophages in classical biotype Vibrio cholerae: functional phage genes but dysfunctional phage genomes. J Bacteriol. 2000 Dec;182(24):6992-8.

22: Davis BM, Waldor MK. CTXphi contains a hybrid genome derived from tandemly integrated elements. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8572-7.

23: Davis BM, Lawson EH, Sandkvist M, Ali A, Sozhamannan S, Waldor MK. Convergence of the secretory pathways for cholera toxin and the filamentous phage, CTXphi. Science. 2000 Apr 14;288(5464):333-5.

24: Davis BM, Kimsey HH, Chang W, Waldor MK. The Vibrio cholerae O139 Calcutta bacteriophage CTXphi is infectious and encodes a novel repressor. J Bacteriol. 1999 Nov;181(21):6779-87.

25: Davis BM, McCurrach ME, Taneja KL, Singer RH, Housman DE. Expansion of a CUG trinucleotide repeat in the 3′ untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7388-93.

26: Reddy S, Smith DB, Rich MM, Leferovich JM, Reilly P, Davis BM, Tran K, Rayburn H, Bronson R, Cros D, Balice-Gordon RJ, Housman D. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nat Genet. 1996 Jul;13(3):325-35.